Mutual effect of glucose and glutamine on their utilization by tumour cells.

Interactions between glucose and glutamine metabolisms have been studied in a line of Ehrlich ascites tumour cells and the results obtained are compared with those recently published for ascites Lettré cells. In contrast with Lettré cells, in the less malignant line used in this work, glucose did not modify glutaminolytic flux and glutamine changed the rate of glucose consumption. It is concluded that the biochemical behaviour of the cells could be correlated to the degree of malignancy.