Caulet S, Capron F, Laaban J P, Prudent J, Rochemaure J, Diebold J
Service Central d'Anatomie et de Cytologie Pathologiques Jacques Delarue, Hôtel-Dieu, Paris.
Ann Pathol. 1990;10(3):177-80.
Aspergillosis with fatal outcome are usually pulmonary invasive aspergillosis with or without dissemination, developed in patients with severe immunosuppression. We report a fatal case of bronchial necrotizing aspergillosis in a young woman with diabetes mellitus, who developed similar lesions to "Semi-invasive Aspergillosis", so-called "Chronic Necrotizing Pulmonary Aspergillosis". This aspergillosis was complicated by large pulmonary artery aneurysms requiring an hemostatic lobectomy. These aneurysms, secondary to the bronchial lesions, contrast with infectious aneurysms (so-called mycotic) secondary to septic embols. They differ from Rasmussen's aneurysms, due to tuberculosis, by their size, fusiform shape and extent. Lesions of vessels' walls and parietal fungal invasion in the vicinity of an endo-bronchial aspergilloma explain the vascular rupture. The multiplicity of these aneurysms, showed on C T Scan, is responsible for death by post-surgical recurrence of hemoptysis.
导致死亡的曲霉病通常是伴有或不伴有播散的肺侵袭性曲霉病,发生于严重免疫抑制的患者。我们报告了一例患有糖尿病的年轻女性发生支气管坏死性曲霉病并致死的病例,该病例出现了与“半侵袭性曲霉病”(即所谓的“慢性坏死性肺曲霉病”)相似的病变。这种曲霉病并发了巨大肺动脉瘤,需要进行止血性肺叶切除术。这些继发于支气管病变的动脉瘤与继发于脓毒性栓子的感染性动脉瘤(所谓的霉菌性动脉瘤)不同。它们在大小、梭形形状和范围方面与因结核病导致的拉斯姆森动脉瘤不同。支气管内曲菌球附近血管壁的病变和壁层真菌浸润解释了血管破裂的原因。CT扫描显示的这些动脉瘤的多发性是术后咯血复发导致死亡的原因。