Piracha Shahbaz, Mahmood Asad, Qayyum Noman, Ganaie Muhammad Badar
Department of Respiratory Medicine, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
Department of Radiology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
BMJ Case Rep. 2018 Apr 19;2018:bcr-2017-223088. doi: 10.1136/bcr-2017-223088.
A 68-year-old man, presented with 3 week history of infective symptoms and mild haemoptysis. Past medical history included severe emphysema and a chronic right upper lobe (RUL) cavity. He was discharged from follow-up a year ago in view of clinical and radiological stability; previous bronchoscopic examinations yielded no specific diagnosis. CT scan on admission confirmed complex cavitary consolidation of RUL. He developed massive haemoptysis requiring intubation and ventilation. CT pulmonary angiogram (CTPA) revealed 16 mm RUL pulmonary artery (PA) aneurysm which was successfully embolized. Sputum cultures, aspergillus antigen and rapidity of clinical progression suggested a diagnosis of subacute invasive aspergillosis (SAIA), prompting treatment with Voriconazole. Bronchoscopy showed blood ooze from RUL even after embolization. Unfortunately, patient continued to deteriorate and succumbed to profound septicaemia.
一名68岁男性,有3周的感染症状和轻度咯血病史。既往病史包括严重肺气肿和右肺上叶慢性空洞。鉴于临床和影像学稳定,他一年前停止随访;之前的支气管镜检查未明确诊断。入院时的CT扫描证实右肺上叶有复杂的空洞性实变。他出现大量咯血,需要插管和通气。CT肺动脉造影(CTPA)显示右肺上叶肺动脉(PA)有一个16毫米的动脉瘤,已成功栓塞。痰培养、曲霉抗原和临床进展速度提示诊断为亚急性侵袭性曲霉病(SAIA),于是开始使用伏立康唑治疗。支气管镜检查显示,即使在栓塞后,右肺上叶仍有渗血。不幸的是,患者病情继续恶化,最终死于严重败血症。