UNSW Water Research Centre, School of Civil and Environmental Engineering, University of New South Wales, Sydney, Australia.
J Chromatogr A. 2013 Aug 16;1303:66-75. doi: 10.1016/j.chroma.2013.06.006. Epub 2013 Jun 14.
Galaxolide (HHCB), tonalide (AHTN), phantolide (AHDI), traseolide (ATII) and cashmeran (DPMI) are synthetic polycyclic musks (PCMs). They are all commonly used in fragrance industries as racemic mixtures. A sensitive and robust enantioselective analytical method was developed to facilitate measurement of these chemicals in wastewater and environmental samples. The method is based on gas chromatography with tandem mass spectrometry (GC-MS/MS). Enantioseparation was assessed using four commercially available chiral capillary columns. Optimised resolution was achieved using a dual-column configuration of a chiral heptakis(2,3- di-O-methyl-6-O-t-butyl dimethylsilyl)-β-cyclodextrin column combined with a (non-chiral) HP-5MS column. This configuration was demonstrated to be capable of effectively resolving all commercially manufactured enantiomers of these five PCMs. Method detection limits for single enantiomers in drinking water and surface water range between 1.01 and 2.39ngL(-1). Full validation of the application of this method in these aqueous matrices is provided.
加乐麝香（HHCB）、檀香麝香（AHTN）、仙乐麝香（AHDI）、吐纳麝香（ATII）和广藿香麝香（DPMI）是合成多环麝香（PCMs）。它们都被广泛应用于香料工业中，作为外消旋混合物。本文开发了一种灵敏而强大的对映体选择性分析方法，以便于测量废水和环境样品中的这些化学物质。该方法基于气相色谱与串联质谱联用（GC-MS/MS）。使用四种市售的手性毛细管柱评估对映体分离。通过使用手性七（2,3-二-O-甲基-6-O-叔丁基二甲基硅基）-β-环糊精柱与（非手性）HP-5MS 柱的双柱配置实现了最佳分辨率。该配置被证明能够有效地分离这五种 PCM 的所有市售对映异构体。在饮用水和地表水中单一对映体的方法检测限在 1.01 到 2.39ngL(-1)之间。提供了该方法在这些水基质中应用的全面验证。
