Department of Pharmacology, Vascular Research Unit, Ghent University, Belgium.
Metabolism. 2013 Nov;62(11):1513-21. doi: 10.1016/j.metabol.2013.06.004. Epub 2013 Jul 15.
Adipose tissue can be considered as a huge gland producing paracrine and endocrine hormones, the adipo(cyto)kines. There is growing evidence that these adipo(cyto)kines may link obesity to cardiovascular diseases. The excessive adipocyte hypertrophy in obesity induces hypoxia in adipose tissue. This leads to adiposopathy, the process that converts "healthy" adipose tissue to "sick" adipose tissue. This is accompanied by a change in profile of adipo(cyto)kines released, with less production of the "healthy" adipo(cyto)kines such as adiponectin and omentin and more release of the "unhealthy" adipo(cyto)kines, ultimately leading to the development of cardiovascular diseases. The present review provides a concise and general overview of the actual concepts of the role of adipo(cyto)kines in endothelial dysfunction, hypertension, atherosclerosis and heart diseases. The knowledge of these concepts may lead to new tools to improve health in the next generations.
脂肪组织可以被视为一个产生旁分泌和内分泌激素的巨大腺体，即脂肪细胞因子。越来越多的证据表明，这些脂肪细胞因子可能将肥胖与心血管疾病联系起来。肥胖导致脂肪细胞过度肥大，从而导致脂肪组织缺氧。这导致脂肪病，即“健康”脂肪组织转化为“病态”脂肪组织的过程。这伴随着释放的脂肪细胞因子谱的变化，“健康”的脂肪细胞因子（如脂联素和网膜素）的产生减少，而“不健康”的脂肪细胞因子（如瘦素）的释放增加，最终导致心血管疾病的发生。本综述简要概述了脂肪细胞因子在血管内皮功能障碍、高血压、动脉粥样硬化和心脏病中的作用的现有概念。对这些概念的了解可能会为下一代人的健康带来新的工具。
