Section for Clinical Neurophysiology and Multimodal Neuroimaging, Department of Child and Adolescent Psychiatry, Technical University Dresden, Fetscherstraße 74, D-01307 Dresden, Germany; Section for Experimental Psychopathology, Psychiatric Hospital, University of Heidelberg, Voßstraße 4, D-69115 Heidelberg, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt/Main, Deutschordenstraße 50, D-60528 Frankfurt/Main, Germany.
Section for Clinical Neurophysiology and Multimodal Neuroimaging, Department of Child and Adolescent Psychiatry, Technical University Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
Clin Neurophysiol. 2014 Jan;125(1):53-62. doi: 10.1016/j.clinph.2013.05.026. Epub 2013 Jul 15.
To investigate whether automatic auditory post-processing is deficient in patients with Alzheimer's disease and is related to sensory gating.
Event-related potentials were recorded during a passive listening task to examine the automatic transient storage of auditory information (short click pairs). Patients with Alzheimer's disease were compared to a healthy age-matched control group. A young healthy control group was included to assess effects of physiological aging.
A bilateral frontal negativity in combination with deep temporal positivity occurring 500 ms after stimulus offset was reduced in patients with Alzheimer's disease, but was unaffected by physiological aging. Its amplitude correlated with short-term memory capacity, but was independent of sensory gating in healthy elderly controls. Source analysis revealed a dipole pair in the anterior temporal lobes.
Results suggest that auditory post-processing is deficient in Alzheimer's disease, but is not typically related to sensory gating. The deficit could neither be explained by physiological aging nor by problems in earlier stages of auditory perception. Correlations with short-term memory capacity and executive control tasks suggested an association with memory encoding and/or overall cognitive control deficits.
An auditory late negative wave could represent a marker of auditory working memory encoding deficits in Alzheimer's disease.
探讨阿尔茨海默病患者的自动听觉后加工是否存在缺陷，以及这种缺陷是否与感觉门控有关。
在被动听任务中记录事件相关电位，以检查听觉信息的自动瞬态存储（短点击对）。将阿尔茨海默病患者与年龄匹配的健康对照组进行比较。纳入年轻健康对照组以评估生理老化的影响。
与刺激后偏移 500 毫秒时出现的双侧额部负性和深部颞部正性相关的自动瞬态存储在阿尔茨海默病患者中减少，但不受生理老化的影响。其幅度与短期记忆能力相关，但在健康老年人对照组中与感觉门控无关。源分析显示在前颞叶有一对偶极子。
结果表明，阿尔茨海默病患者的听觉后加工存在缺陷，但通常与感觉门控无关。这种缺陷既不能用生理老化来解释，也不能用听觉感知早期阶段的问题来解释。与短期记忆能力和执行控制任务的相关性表明，它与记忆编码和/或整体认知控制缺陷有关。
听觉晚负波可能代表阿尔茨海默病听觉工作记忆编码缺陷的标志物。
