Pekkonen E, Jousmäki V, Könönen M, Reinikainen K, Partanen J
Department of Neurology, University Hospital of Kuopio, Finland.
Neuroreport. 1994 Dec 20;5(18):2537-40. doi: 10.1097/00001756-199412000-00033.
Auditory event-related potentials (ERP) were recorded from 10 healthy older subjects and 9 patients with Alzheimer's disease (AD) to investigate whether auditory sensory memory is impaired in AD. Standard (85%) and deviant (15%) tones were presented in random order with interstimulus intervals (ISI) of 1 s or 3 s in separate blocks. Deviant tones elicited a specific ERP component called mismatch negativity (MMN) which reflects automatic stimulus change detection and thus presumably, the neural basis of sensory memory in audition. The MMN amplitude decreased as a function of the ISI more in the AD group than in the control group. This suggests that the memory trace decays faster in the AD patients than in age-matched healthy controls.
对10名健康的老年受试者和9名阿尔茨海默病（AD）患者进行听觉事件相关电位（ERP）记录，以研究AD患者的听觉感觉记忆是否受损。标准音（85%）和偏差音（15%）以随机顺序呈现，在不同的组块中刺激间隔（ISI）分别为1秒或3秒。偏差音引发一种名为失配负波（MMN）的特定ERP成分，它反映了对刺激变化的自动检测，因此推测是听觉中感觉记忆的神经基础。与对照组相比，AD组中MMN波幅随ISI的增加下降得更多。这表明AD患者的记忆痕迹比年龄匹配的健康对照组衰退得更快。
