Abuhandan M, Bozkuş F, Demir N, Eren E, Koca B, Kadir Guler O, Selek S
Department of Pediatrics, Harran University Medical Faculty, Sanliurfa, Turkey.
Clin Ter. 2013 May-Jun;164(3):e163-7. doi: 10.7417/CT.2013.1562.
This study aimed to evaluate the preoperative and postoperative oxidative status of children with chronic adenotonsillar hypertrophy.
The study comprised 25 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 25 age-gender matched control patients were included to the study. Blood samples were taken from the patients preoperatively and at four weeks postoperatively. Preoperative and postoperative serum total oxidant (TOS) and total antioxidant (TAS) levels were measured and the oxidative stress index (OSI) was calculated.
The serum total oxidant level and oxidant stress index values in the preoperative and postoperative periods of the patients were found to be significantly high compared to those of the control group. While the preoperative serum total oxidant level values were found to be significantly high compared to the postoperative values, no statistical significance was found between the total antioxidant and oxidative stress index values.
The development of chronic adenotonsillar hypertrophy plays a role in oxidative status and therefore, to neutralize high levels of oxidants in patients, the use of antioxidants for a period preoperatively and postoperatively is thought to be necessary.
