Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden.
Blood. 2013 Sep 5;122(10):1789-92. doi: 10.1182/blood-2013-05-502807. Epub 2013 Jul 18.
Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phases of the disease. Furthermore, the gene expression levels of several cytokines differed between the 2 phases of the disease. This was also reflected in plasma with increased levels of interleukin (IL)-16 and TNF-related weak inducer of apoptosis and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that chronic ITP in childhood is a separate disease entity, dissimilar in many aspects to the newly diagnosed phase.
免疫性血小板减少症（ITP）是一种自身免疫性疾病，其中血小板过早被破坏。在大多数儿童中，疾病会自行消退，但在某些儿童中，疾病会变成慢性。为了研究疾病的这两个阶段在分子上是否相似或属于不同的实体，我们对新诊断的儿童和慢性 ITP 儿童的 T 细胞进行了 DNA 微阵列分析（GEO 注册号：GSE46922）。我们发现疾病的两个阶段之间的基因表达谱完全分离。此外，几种细胞因子的基因表达水平在疾病的两个阶段之间存在差异。这也反映在血浆中，与慢性 ITP 相比，新诊断的 ITP 中白细胞介素（IL）-16 和 TNF 相关凋亡弱诱导物的水平升高，而 IL-4 的水平降低。因此，我们的数据表明，儿童慢性 ITP 是一种独立的疾病实体，在许多方面与新诊断的阶段不同。
