Huang T B
Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University of Medical Sciences, Guangzhon, People's Republic of China.
Cancer. 1990 Sep 1;66(5):968-71. doi: 10.1002/1097-0142(19900901)66:5<968::aid-cncr2820660527>3.0.co;2-a.
Between 1964 and 1983, 54,304 cases of nasopharyngeal carcinoma (NPC) patients were diagnosed at the Tumor Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, People's Republic of China. Of the total, 53 (0.1%) cases were younger than 14 years of age, and of these, none were Stage I, four (8%) were Stage II, 36 (68%) were Stage III, and 12 (23%) were Stage IV. Among all cases, 26% had initial symptoms characterized by lesions of the nasopharynx and the majority by cervical mass. Among the children, symptoms involving the cranial nerve were rarely observed. There were significant differences between adults and children on histopathology other than the ratio of carcinoma to sarcoma (4:1 for children; 443:1 for adults). Among the poorly differentiated carcinoma cases, vesicular nucleus carcinoma was observed more frequently in children than adults. The prognosis for children with NPC is poor with a 5-year survival rate of 21% in this series. If NPC is diagnosed early and radiotherapy begun promptly (with doses greater than 5000 cGy), the prognosis may be improved.
1964年至1983年间，中华人民共和国广州中山医科大学肿瘤医院诊断出54304例鼻咽癌患者。其中，53例（0.1%）患者年龄小于14岁，这些患者中无I期病例，4例（8%）为II期，36例（68%）为III期，12例（23%）为IV期。所有病例中，26%的初始症状以鼻咽部病变为特征，大多数以颈部肿块为特征。在儿童中，很少观察到涉及颅神经的症状。除癌与肉瘤的比例外（儿童为4:1；成人为443:1），成人和儿童在组织病理学方面存在显著差异。在低分化癌病例中，儿童泡状核细胞癌的观察频率高于成人。本系列中，鼻咽癌儿童患者的预后较差，5年生存率为21%。如果鼻咽癌能早期诊断并及时开始放疗（剂量大于5000 cGy），预后可能会改善。
