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一例原发性中枢神经系统淋巴瘤患者鞘内化疗相关的马尾综合征病例。

A case of the cauda equina syndrome associated with the intrathecal chemotherapy in a patient with primary central nervous system lymphoma.

作者信息

Park Seunglee, Kang Jung-Il, Bang Hyun, Kim Bo-Ram, Lee Jongmin

机构信息

Department of Rehabilitation Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

出版信息

Ann Rehabil Med. 2013 Jun;37(3):420-5. doi: 10.5535/arm.2013.37.3.420. Epub 2013 Jun 30.

DOI:10.5535/arm.2013.37.3.420
PMID:23869341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3713300/
Abstract

The intrathecal chemotherapy with methotrexate and cytarabine arabinoside is used for the treatment and prophylaxis of the primary central nervous system lymphoma. The therapy may induce neurotoxicity including the cauda equina syndrome. We report a case of a 58-year-old man with the diffuse large B-cell lymphoma, who developed the cauda equina syndrome after the administration of intrathecal methotrexate and cytarabine arabinoside, as diagnosed by the electrodiagnostic, urodynamic, and radiologic approaches.

摘要

鞘内注射甲氨蝶呤和阿糖胞苷用于原发性中枢神经系统淋巴瘤的治疗和预防。该治疗可能诱发包括马尾综合征在内的神经毒性。我们报告一例58岁弥漫性大B细胞淋巴瘤男性患者，在鞘内注射甲氨蝶呤和阿糖胞苷后出现马尾综合征，通过电诊断、尿动力学和放射学方法确诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b2/3713300/8ce70bf774a4/arm-37-420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b2/3713300/8ce70bf774a4/arm-37-420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b2/3713300/8ce70bf774a4/arm-37-420-g001.jpg

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本文引用的文献

1
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Best Pract Res Clin Haematol. 2012 Mar;25(1):119-30. doi: 10.1016/j.beha.2011.12.001. Epub 2012 Feb 5.
2
Intrathecal chemotherapy for hematologic malignancies: drugs and toxicities.血液系统恶性肿瘤的鞘内化疗：药物与毒性
Ann Hematol. 2009 Mar;88(3):193-201. doi: 10.1007/s00277-008-0645-y. Epub 2008 Dec 3.
3
Irreversible paraplegia following one time prophylactic intrathecal chemotherapy in an adult patient with acute lymphoblastic leukemia.一名成年急性淋巴细胞白血病患者单次鞘内预防性化疗后发生不可逆性截瘫。
马尾综合征患者肌电图和尿动力学检查的预测能力研究
Acta Inform Med. 2016 Oct;24(5):328-331. doi: 10.5455/aim.2016.24.328-331. Epub 2016 Nov 1.
4
FDG-Avid Intrathecal Inflammation Following Administration of Intrathecal Methotrexate.鞘内注射甲氨蝶呤后出现的氟代脱氧葡萄糖摄取增加的鞘内炎症
Clin Nucl Med. 2016 Dec;41(12):995-997. doi: 10.1097/RLU.0000000000001440.
Yonsei Med J. 2008 Feb 29;49(1):151-4. doi: 10.3349/ymj.2008.49.1.151.
4
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.对于急性淋巴细胞白血病患者，预防性给予鞘内注射脂质体阿糖胞苷联合大剂量甲氨蝶呤和阿糖胞苷时出现的神经系统并发症。
Blood. 2007 Apr 15;109(8):3214-8. doi: 10.1182/blood-2006-08-043646. Epub 2007 Jan 5.
5
Effect of dose and schedule on pharmacokinetics of high-dose cytosine arabinoside in plasma and cerebrospinal fluid.剂量和给药方案对大剂量阿糖胞苷在血浆和脑脊液中药物动力学的影响。
J Clin Oncol. 1983 Sep;1(9):546-51. doi: 10.1200/JCO.1983.1.9.546.
6
Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia.脑膜白血病中的神经毒性和脑脊液甲氨蝶呤浓度升高
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7
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