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一名8岁急性淋巴细胞白血病男孩的药物性马尾综合征：一例罕见病例报告

Drug-Induced Cauda Equina Syndrome in an 8-Year-Old Boy With Acute Lymphoblastic Leukemia: An Uncommon Case Report.

作者信息

Babaee Marzieh, Javadzadeh Mohsen, Hazeghi Ali

机构信息

Physical Medicine and Rehabilitation Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.

Pediatric Neurology Department, Pediatric Neurology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2025 Jan 16;13(1):e70122. doi: 10.1002/ccr3.70122. eCollection 2025 Jan.

DOI:10.1002/ccr3.70122
PMID:39822883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736872/
Abstract

Intrathecal methotrexate can cause cauda equina syndrome in pediatric ALL patients, as demonstrated in this rare case of an 8-year-old boy. Symptoms included progressive limb weakness and urinary retention. Early recognition, prompt discontinuation of the offending agent, and multidisciplinary management are crucial. Vigilant neurological monitoring is essential for pediatric acute lymphoblastic leukemia patients receiving intrathecal chemotherapy.

摘要

鞘内注射甲氨蝶呤可导致小儿急性淋巴细胞白血病（ALL）患者发生马尾综合征，本病例为一名8岁男孩，实属罕见。症状包括进行性肢体无力和尿潴留。早期识别、及时停用致病药物以及多学科管理至关重要。对于接受鞘内化疗的小儿急性淋巴细胞白血病患者，进行密切的神经学监测必不可少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/11736872/febfe1f998cf/CCR3-13-e70122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/11736872/febfe1f998cf/CCR3-13-e70122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/11736872/febfe1f998cf/CCR3-13-e70122-g001.jpg

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本文引用的文献

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Iran J Child Neurol. 2023 Fall;17(4):9-22. doi: 10.22037/ijcn.v17i4.43124. Epub 2023 Oct 26.
2
Acute neurological complications during acute lymphoblastic leukemia therapy: A single-center experience over 10 years.急性淋巴细胞白血病治疗期间的急性神经系统并发症：10 年单中心经验。
Indian J Cancer. 2021 Oct-Dec;58(4):545-552. doi: 10.4103/ijc.IJC_422_19.
3
Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients.
成人鞘内化疗的并发症：109例连续患者的单机构经验
J Oncol. 2019 May 2;2019:4047617. doi: 10.1155/2019/4047617. eCollection 2019.
4
Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review.急性腰骶部多神经根神经病作为甲氨蝶呤鞘内注射神经毒性的早期表现：病例报告及文献复习
Clin Case Rep. 2019 Feb 19;7(4):638-643. doi: 10.1002/ccr3.2026. eCollection 2019 Apr.
5
Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma.帕博利珠单抗治疗转移性黑色素瘤期间的运动性多神经根病
Muscle Nerve. 2017 Dec;56(6):E162-E167. doi: 10.1002/mus.25672. Epub 2017 May 16.
6
Myelopathy following intrathecal chemotherapy in adults: a single institution experience.成人鞘内化疗后脊髓病：单机构经验
J Neurooncol. 2015 Apr;122(2):391-8. doi: 10.1007/s11060-015-1727-z. Epub 2015 Feb 10.
7
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.甲氨蝶呤诱导的儿童急性淋巴细胞白血病的神经毒性和脑白质病。
J Clin Oncol. 2014 Mar 20;32(9):949-59. doi: 10.1200/JCO.2013.53.0808. Epub 2014 Feb 18.
8
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