1 Center for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles , Los Angeles, California.
Diabetes Technol Ther. 2013 Nov;15(11):929-34. doi: 10.1089/dia.2013.0132. Epub 2013 Jul 19.
Increasing numbers of children and adolescents with type 1 diabetes (T1D) have been placed on insulin pump therapy. Nevertheless, data are limited regarding patterns of pump use during the first year of treatment and the clinical and socioeconomic factors associated with early use of pump therapy. Therefore, we sought to determine factors associated with pump therapy within the first year of diagnosis in youth enrolled in the Pediatric Diabetes Consortium (PDC) T1D New-Onset (NeOn) Study.
The NeOn Study includes youth <19 years old at T1D diagnosis who have been followed from the time of diagnosis at seven U.S. pediatric diabetes centers. Cox regression was used to determine factors associated with transition from injection to pump therapy during the first year of T1D in 1,012 participants.
Twenty-seven percent (n=254) of participants began pump therapy within the first year of diagnosis, ranging from 18% to 59% among the seven centers. After adjusting for center effect, factors associated with pump use in multivariate analysis included private health insurance (37% vs. 7%; P<0.001), having annual household income over $100,000 (50% vs. 15%; P<0.001), and non-Hispanic white race (36% vs. 11%; P<0.001). The hemoglobin A1c level did not appear to influence the decision to initiate pump use.
Participants of non-Hispanic white race and higher socioeconomic status were more likely to be placed on pumps during the first year. Further investigations are needed to gain a better understanding of barriers to use of pumps in youth with T1D, especially in disadvantaged and minority families.
越来越多的儿童和青少年 1 型糖尿病(T1D)患者已开始接受胰岛素泵治疗。然而,关于治疗开始后第一年的泵使用模式以及与早期泵治疗相关的临床和社会经济因素的数据有限。因此,我们旨在确定在儿科糖尿病联合会(PDC)T1D 新发病例(NeOn)研究中纳入的青少年在诊断后第一年与泵治疗相关的因素。
NeOn 研究包括在七个美国儿科糖尿病中心就诊的 19 岁以下的 T1D 新诊断患者。我们使用 Cox 回归来确定 1012 名参与者在 T1D 发病后的第一年从注射治疗向泵治疗过渡的相关因素。
27%(n=254)的参与者在诊断后的第一年开始使用泵治疗,七个中心的比例在 18%至 59%之间。在调整中心效应后,多变量分析中与泵使用相关的因素包括私人健康保险(37%比 7%;P<0.001)、年收入超过 100000 美元(50%比 15%;P<0.001)和非西班牙裔白人种族(36%比 11%;P<0.001)。血红蛋白 A1c 水平似乎并未影响启动泵使用的决策。
非西班牙裔白人和社会经济地位较高的参与者在第一年更有可能使用泵。需要进一步调查以更好地了解 T1D 青少年使用泵的障碍,特别是在弱势和少数民族家庭中。