发展一种简便的分子内 Pauson-Khand 反应方法，以立体选择性地构建具有 C1 季碳手性中心的反式十氢萘。
Development of an expedient intramolecular Pauson-Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center.
机构信息
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
出版信息
Chem Commun (Camb). 2013 Oct 9;49(78):8806-8. doi: 10.1039/c3cc45170d.
PMID:23959504
Abstract
Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson-Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.
摘要
通过 Pauson-Khand 反应 (PKR) 作为关键步骤，实现了具有确定 C1 季碳手性中心的反式十氢萘亚基的立体选择性合成。所开发的化学提供了一种替代 IMDA 反应的方法，该方法已用于合成基于反式十氢萘的生物活性天然产物。
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