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Structural characterization and inhibition of toxic amyloid-β oligomeric intermediates.

作者信息

Ramamoorthy Ayyalusamy, Lim Mi Hee

机构信息

Department of Chemistry, The University of Michigan, Ann Arbor, Michigan, USA.

出版信息

Biophys J. 2013 Jul 16;105(2):287-8. doi: 10.1016/j.bpj.2013.05.004.

DOI:10.1016/j.bpj.2013.05.004
PMID:23870249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3714932/
Abstract
摘要

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Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species.深入了解绿茶提取物（-）-表没食子儿茶素-3-没食子酸酯对金属相关淀粉样β 物种的抗淀粉样特性。
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3743-8. doi: 10.1073/pnas.1220326110. Epub 2013 Feb 20.
3
Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption.通过（19）氟核磁共振检测单体消耗动力学来区分人胰岛淀粉样多肽聚集的替代途径。
Biochemistry. 2012 Oct 16;51(41):8154-62. doi: 10.1021/bi3012548. Epub 2012 Oct 1.
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Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation.Aβ 通过膜碎片形成和孔形成破坏膜的两步机制。
Biophys J. 2012 Aug 22;103(4):702-10. doi: 10.1016/j.bpj.2012.06.045.
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Misfolded proteins in Alzheimer's disease and type II diabetes.阿尔茨海默病和 2 型糖尿病中的错误折叠蛋白。
Chem Soc Rev. 2012 Jan 21;41(2):608-21. doi: 10.1039/c1cs15112f. Epub 2011 Aug 4.
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A partially folded structure of amyloid-beta(1-40) in an aqueous environment.淀粉样蛋白β（1-40）在水相环境中的部分折叠结构。
Biochem Biophys Res Commun. 2011 Jul 29;411(2):312-6. doi: 10.1016/j.bbrc.2011.06.133. Epub 2011 Jun 25.
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Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins.无机纳米粒子抑制淀粉样肽纤维形成：与蛋白质的功能相似性。
Angew Chem Int Ed Engl. 2011 May 23;50(22):5110-5. doi: 10.1002/anie.201007824. Epub 2011 Apr 14.
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Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions.人血清白蛋白-阿尔茨海默病 Aβ肽相互作用的化学计量学和亲和力。
Biophys J. 2011 Jan 5;100(1):183-92. doi: 10.1016/j.bpj.2010.11.037.
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Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.设计靶向金属-Aβ物种的小分子，并调节金属诱导的 Aβ聚集和神经毒性。
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):21990-5. doi: 10.1073/pnas.1006091107. Epub 2010 Dec 3.
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Small molecule modulators of copper-induced Abeta aggregation.铜诱导的 Abeta 聚集的小分子调节剂。
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