普萘洛尔对血管对交感神经刺激反应的影响。
The effect of propranolol on vascular responses to sympathetic nerve stimulation.
作者信息
Dawes P M, Faulkner D C
出版信息
Br J Pharmacol. 1975 Apr;53(4):517-24. doi: 10.1111/j.1476-5381.1975.tb07389.x.
Abstract
- In an attempt to clarify the role of the sympathetic neurone in the antihypertensive action of propranolol, the effect of this drug on responses to lumbar sympathetic nerve stimulation has been studied in the perfused hind-limb of the dog. 2. No consistent reduction of maximal or submaximal responses to nerve stimulation was produced by propranolol (10 to 100 mug/kg). In contrast, potentiation of nerve-evoked response, as well as those to injected noradrenaline, usually occurred. Dexpropranolol (50 mug/kg) had no effect. 3. When neuronal uptake of noradrenaline was inhibited by desmethylimipramine or cacaine, no reduction in responses to sympathetic nerve stimulation was observed with propranolol. 4. No evidence was found, using alpha-adrenoceptor blocking drugs, that released transmitter stimulates beta-adrenoceptors in the blood vessels of the hind-limb. 5. No evidence has been found for the existence of an adrenergic neurone-blocking action of propranolol that might contribute to the antihypertensive activity in man.
摘要
- 为了阐明交感神经元在普萘洛尔降压作用中的作用，已在犬的灌注后肢中研究了该药对腰交感神经刺激反应的影响。2. 普萘洛尔（10至100微克/千克）未使对神经刺激的最大或次最大反应产生一致的降低。相反，神经诱发反应以及对注射去甲肾上腺素的反应通常会增强。右旋普萘洛尔（50微克/千克）无作用。3. 当去甲肾上腺素的神经元摄取被去甲丙咪嗪或卡卡因抑制时，未观察到普萘洛尔使对交感神经刺激的反应降低。4. 使用α-肾上腺素受体阻断药物未发现有证据表明释放的递质刺激后肢血管中的β-肾上腺素受体。5. 未发现有证据表明普萘洛尔存在肾上腺素能神经元阻断作用，这种作用可能有助于人类的降压活性。
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