蒲桃和刺角瓜顺势疗法制剂对高脂高果糖诱导的2型糖尿病大鼠腓肠肌的影响。

Effect of homeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high fat and high fructose-induced type-2 diabetic rats.

作者信息

Sampath Sathish, Narasimhan Akilavalli, Chinta Raveendar, Nair K R Janardanan, Khurana Anil, Nayak Debadatta, Kumar Alok, Karundevi Balasubramanian

机构信息

Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Sekkizhar Campus, Taramani, Chennai 600113, India.

出版信息

Homeopathy. 2013 Jul;102(3):160-71. doi: 10.1016/j.homp.2013.05.002.

DOI:10.1016/j.homp.2013.05.002

PMID:23870375

Abstract

BACKGROUND

Homeopathy is a holistic method of treatment that uses microdoses of natural substances originating from plants, minerals, or animal parts. Syzygium jambolanum and Cephalandra indica are used in homeopathy for treatment of type-2 diabetes. However, the molecular mechanisms responsible for such effects are not known.

METHODS

Homeopathic preparations of S. jambolanum and C. indica in mother tincture, 6c and 30c were used to examine the molecular mechanism of antidiabetic effects in the skeletal muscle of rats with high fat and fructose-induced type-2 diabetes mellitus. After 30 days treatment, fasting blood glucose, serum insulin and insulin signaling molecules in the skeletal muscle (gastrocnemius) were measured.

RESULTS

Diabetic rats showed a significant decrease in serum insulin and lipid profile as well as low levels of insulin receptor (IR), v-akt murine thymoma viral oncogene homolog (Akt), p-Akt(ser473) and glucose transporter-4 (GLUT4) protein expression (p < 0.05) with a significant increase in fasting blood glucose level (p < 0.05) compared to the control group. Treatment with homeopathic remedies significantly increased the serum insulin and expression of these proteins (p < 0.05) with a significant decrease in fasting blood glucose (p < 0.05) compared to diabetic rats.

CONCLUSIONS

In the present study homeopathic preparations of S. jambolanum and C. indica, including ultramolecular dilutions exhibit antidiabetic effects, improving insulin action through activation of insulin signaling molecules in skeletal muscle of type-2 diabetic rats.

摘要

背景

顺势疗法是一种整体治疗方法，使用源自植物、矿物质或动物部位的天然物质的微量剂量。蒲桃和刺角瓜在顺势疗法中用于治疗2型糖尿病。然而，导致这种作用的分子机制尚不清楚。

方法

使用母酊剂、6c和30c浓度的蒲桃和刺角瓜顺势疗法制剂，研究高脂和果糖诱导的2型糖尿病大鼠骨骼肌中抗糖尿病作用的分子机制。治疗30天后，测量空腹血糖、血清胰岛素和骨骼肌（腓肠肌）中的胰岛素信号分子。

结果

与对照组相比，糖尿病大鼠血清胰岛素和血脂水平显著降低，胰岛素受体（IR）、v-akt小鼠胸腺瘤病毒癌基因同源物（Akt）、p-Akt（ser473）和葡萄糖转运蛋白4（GLUT4）蛋白表达水平较低（p < 0.05），空腹血糖水平显著升高（p < 0.05）。与糖尿病大鼠相比，顺势疗法制剂治疗显著提高了血清胰岛素和这些蛋白的表达水平（p < 0.05），空腹血糖显著降低（p < 0.05）。