Zwennis W C, Franssen A C, Wijnans M J
Department of Occupational Toxicology, TNO Medical Biological Laboratory, Rijswijk, The Netherlands.
Clin Chem. 1990 Aug;36(8 Pt 1):1456-9.
We studied the relation between the concentrations of lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) in a group of 801 men occupationally exposed for more than one year to lead or inorganic lead compounds. Linear regression of PbB on log ZPP provided 95% tolerance intervals for PbB values for a given ZPP value. The intervals we found are too large to warrant the estimation of PbB on the basis of ZPP measurements in health surveillance of lead workers. Instead we propose a procedure in which ZPP can be used as an indicator to decide which individuals exposed to lead need further investigation of PbB in light of existing limit values for PbB. The procedure is applicable only for PbB values of 2.4 mumol/L or more but may reduce considerably the costs for screening individuals or groups of people exposed to lead.
我们研究了801名职业性接触铅或无机铅化合物一年以上的男性血液中铅浓度（PbB）与血液中锌原卟啉（ZPP）之间的关系。PbB对log ZPP的线性回归为给定ZPP值的PbB值提供了95%的容忍区间。我们发现这些区间太大，以至于在铅作业工人的健康监测中无法根据ZPP测量值来估算PbB。相反，我们提出了一种方法，在该方法中，ZPP可用作指标，根据PbB的现有限值来决定哪些接触铅的个体需要进一步检测PbB。该方法仅适用于PbB值为2.4 μmol/L或更高的情况，但可能会大幅降低筛查接触铅的个体或人群的成本。
