Verschoor M, Herber R, Zielhuis R, Wibowo A
Coronel Laboratory for Occupational and Environmental Health, Medical Faculty, University of Amsterdam, The Netherlands.
Int Arch Occup Environ Health. 1987;59(6):613-21. doi: 10.1007/BF00377923.
In lead-exposed workers many factors affect the relationship between the levels of lead and of zinc protoporphyrin (ZPP) in blood. When the zinc protoporphyrin level is used to assess the lead in the blood level, the analytical accuracy of the ZPP and the PbB determinations should be known. Also the variability of lead exposure over time is an important parameter of this assessment. The absolute and relative precision of ZPP measurements with two brands of ZPP meters (AVIV and ESA) were compared. The absolute precision of the ZPP measurements is not constant for the AVIV meter, but is constant for the ESA meter. The relative precision for both brands of meters decreases with increasing ZPP levels. Between the AVIV and the ESA meters, a significant difference in response, irrespective of the kind of anticoagulant used, was observed. The regression equations between PbB and ZPP levels were studied. Different factors can affect the relationship between PbB and ZPP, e.g. variability in lead exposure, the time-lag between the increase of PbB and ZPP, and the precision and accuracy of PbB and ZPP measurements.
在铅暴露工人中，许多因素会影响血液中铅水平与锌原卟啉（ZPP）水平之间的关系。当使用锌原卟啉水平来评估血液中的铅水平时，应该了解ZPP和血铅（PbB）测定的分析准确性。此外，铅暴露随时间的变化也是该评估的一个重要参数。比较了两种品牌的ZPP测量仪（AVIV和ESA）测量ZPP的绝对精度和相对精度。AVIV测量仪测量ZPP的绝对精度并不恒定，而ESA测量仪的则恒定。两种品牌测量仪的相对精度均随ZPP水平的升高而降低。在AVIV和ESA测量仪之间，无论使用何种抗凝剂，均观察到显著的响应差异。研究了血铅与ZPP水平之间的回归方程。不同因素会影响血铅与ZPP之间的关系，例如铅暴露的变异性、血铅升高与ZPP升高之间的时间间隔，以及血铅和ZPP测量的精度和准确性。
