a Colegio Ciencias de la Salud, Escuela de Medicina, Escuela de Salud Pública , Colegio de Artes Liberales y Galapagos Institute for Arts and Sciences GAIAS; Universidad San Francisco de Quito , Quito , Ecuador.
J Toxicol Environ Health A. 2013;76(19):1111-20. doi: 10.1080/15287394.2013.840708.
The purpose of this study was to investigate current blood lead (PbB) and zinc protoporphyrin (ZPP) levels in adults presently living in environmentally Pb-contaminated Andean communities, and to compare the findings with the PbB and ZPP levels of Pb-exposed adult cohorts from the same study area tested between 1996 and 2007. Blood samples from 39 adults were measured for PbB and ZPP concentrations. The current mean PbB level (22.7 μg/dl) was significantly lower than the mean (37.9 μg/dl) of the initial 1996 cohort. PbB levels for the 1997, 1998, 2003, and 2006 cohorts were also significantly lower than the levels for the 1996 group. Elevated ZPP/heme ratios of 103.3, 128.4, and 134.2 μmol/mol were not significantly different for the 2006, 2007, and 2012 groups, indicating chronic Pb exposure. While ZPP levels of Andean Ecuadorian Pb-glazing workers have remained elevated, PbB levels declined. Lead exposure of the workers needs to be continually monitored.
本研究旨在调查目前生活在环境铅污染的安第斯社区的成年人的血液铅（PbB）和锌原卟啉（ZPP）水平，并将这些发现与同一研究区域内 1996 年至 2007 年间测试的 Pb 暴露成人队列的 PbB 和 ZPP 水平进行比较。对 39 名成年人的血液样本进行了 PbB 和 ZPP 浓度的测量。目前的平均 PbB 水平（22.7μg/dl）明显低于 1996 年初始队列的平均水平（37.9μg/dl）。1997 年、1998 年、2003 年和 2006 年的 PbB 水平也明显低于 1996 年组的水平。2006 年、2007 年和 2012 年组的 ZPP/血红素比值分别为 103.3、128.4 和 134.2μmol/mol，均未出现显著差异，表明存在慢性 Pb 暴露。虽然安第斯厄瓜多尔铅釉工的 ZPP 水平仍然升高，但 PbB 水平下降。工人的 Pb 暴露需要持续监测。
