Bromide interference: is less really better?

Increased serum bromide may result from the ingestion of various drugs and from environmental exposures. Chloride methods that are less susceptible to bromide interference have a clinical disadvantage in that they are less likely to arouse suspicion in cases of bromide toxicity. When there is a clinical suspicion of bromide toxicity, differences among various analyzers in the amount of interference caused by bromide may be exploited to confirm this suspicion and to estimate the concentration of bromide in serum.