与阿尔茨海默病及伴发中风相关的载脂蛋白E基因型。
Apolipoprotein E genotypes associated with Alzheimer disease and concomitant stroke.
作者信息
Fekih-Mrissa Najiba, Klai Sarra, Mrad Meriem, Mansour Malek, Zaouali Jamel, Gritli Nasreddine, Mrissa Ridha
机构信息
Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Académie Militaire Fondouk Jédid, Nabeul, Tunisie.
Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis, Tunisie; Faculté des Sciences de Tunis, Université de Tunis El Manar, El Manar, Tunisie.
出版信息
J Stroke Cerebrovasc Dis. 2014 Apr;23(4):681-5. doi: 10.1016/j.jstrokecerebrovasdis.2013.06.018. Epub 2013 Jul 18.
BACKGROUND
The ɛ4 allele of the apolipoprotein E (APOE) gene is a well-characterized genetic risk factor for Alzheimer disease (AD). The association between stroke and a higher risk for AD has also been reported. Our study sought to determine the relationship between the APOE gene and AD and the comorbid risk of stroke.
METHODS
The subjects of this study consisted of 48 patients with AD and 48 members of a control group. All subjects were genotyped for APOE.
RESULTS
The results clearly show a significant increased risk of AD in carriers of the APOE ε3/ε4 genotype (P = .003, odds ratio [OR] = 4.1) or ε4 allele (P = .001, OR = 4.2). The risk for stroke in AD patients was also increased for carriers of the APOE ε3/ε4 genotype (P = .02, OR = 9.0) and for carriers of the APOE ε4 allele (P = .004, OR = 5.5).
CONCLUSIONS
The present study is the first to establish a relationship between APOE ε4 and concomitant AD and stroke in the Tunisian population.
背景
载脂蛋白E（APOE）基因的ε4等位基因是阿尔茨海默病（AD）一个已得到充分研究的遗传风险因素。也有报道称中风与AD的较高风险之间存在关联。我们的研究旨在确定APOE基因与AD之间以及中风的合并风险之间的关系。
方法
本研究的受试者包括48例AD患者和48名对照组成员。对所有受试者进行APOE基因分型。
结果
结果清楚地表明，APOE ε3/ε4基因型携带者（P = 0.003，优势比[OR]=4.1）或ε4等位基因携带者（P = 0.001，OR = 4.2）患AD的风险显著增加。APOE ε3/ε4基因型携带者（P = 0.02，OR = 9.0）和APOE ε4等位基因携带者（P = 0.004，OR = 5.5）患中风的风险也增加。
结论
本研究首次在突尼斯人群中确立了APOE ε4与AD及中风并存之间的关系。
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