Gupta Anuradha, Uthayaseelan Kamsika, Uthayaseelan Kivonika, Kadari Monika, Subhan Muhammad, Saji Parel Nisha, Krishna Parimi Vamsi, Sange Ibrahim
Research, Government Medical College, Nagpur, IND.
Internal Medicine, All Saints University College of Medicine, Saint Vincent and the Grenadines, Kingstown, VCT.
Cureus. 2022 May 15;14(5):e25005. doi: 10.7759/cureus.25005. eCollection 2022 May.
A neurodegenerative disorder, Alzheimer's disease (AD), is characterized by dementia in which there is an age-related decline in cognition and higher functions. Stroke is a cerebrovascular disorder that frequently presents in old age and is a known risk factor for AD development. However, the association that AD can be a risk factor for stroke is not well-studied. This review article compiled various studies that pointed out the association between stroke development in patients with dementia, particularly AD-related dementia. The pathophysiological progression of stroke in AD cases and the genetic makeup possibly affecting the interrelation between these disorders were analyzed in detail using currently available data and studies. Therapeutic and management modalities already in use for AD were put together, and the possibility of early intervention in such patients benefitting cerebrovascular pathologies, particularly stroke-related, was explored. Prognostic differences between patients of stroke with and without AD were also reviewed, and how appropriate management can reduce the burden on health care settings when both present simultaneously was emphasized.
神经退行性疾病阿尔茨海默病（AD）的特征是痴呆，即认知和高级功能出现与年龄相关的衰退。中风是一种常见于老年的脑血管疾病，也是已知的AD发病风险因素。然而，AD是否可能是中风的风险因素这一关联尚未得到充分研究。这篇综述文章汇集了各项研究，这些研究指出了痴呆患者（尤其是与AD相关的痴呆）中风发病之间的关联。利用现有数据和研究，详细分析了AD病例中中风的病理生理进展以及可能影响这些疾病之间相互关系的基因构成。汇总了已用于AD的治疗和管理方式，并探讨了对这类患者进行早期干预使其受益于脑血管疾病（尤其是与中风相关的疾病）的可能性。还回顾了有AD和无AD的中风患者之间的预后差异，并强调了在两者同时出现时适当的管理如何减轻医疗机构的负担。
