Research Center Pharmaceutical Engineering GmbH, A-8010 Graz, Austria.
Int J Pharm. 2013 Sep 15;454(1):381-7. doi: 10.1016/j.ijpharm.2013.07.029. Epub 2013 Jul 18.
The aim of this paper is to study the effect of the speed of capsule filling and the inherent machine vibrations on fill weight for a dosator-nozzle machine. The results show that increasing speed of capsule filling amplifies the vibration intensity (as measured by Laser Doppler vibrometer) of the machine frame, which leads to powder densification. The mass of the powder (fill weight) collected via the nozzle is significantly larger at a higher capsule filling speed. Therefore, there is a correlation between powder densification under more intense vibrations and larger fill weights. Quality-by Design of powder based products should evaluate the effect of environmental vibrations on material attributes, which in turn may affect product quality.
本文旨在研究胶囊填充速度和机器固有振动对定量给料机填充重量的影响。结果表明，增加胶囊填充速度会放大机器框架的振动强度（通过激光多普勒测振仪测量），导致粉末致密化。通过喷嘴收集的粉末质量（填充重量）在更高的胶囊填充速度下显著更大。因此，在更强烈的振动下粉末致密化和更大的填充重量之间存在相关性。基于粉末的产品的质量源于设计应该评估环境振动对材料属性的影响，这反过来又可能影响产品质量。
