Llusa Marcos, Faulhammer Eva, Biserni Stefano, Calzolari Vittorio, Lawrence Simon, Bresciani Massimo, Khinast Johannes
Research Center Pharmaceutical Engineering GmbH, A-8010 Graz, Austria.
MG2, Via del Savena 18, I-40065 Pian di Macina di Pianoro, Bologna, Italy.
Int J Pharm. 2014 Aug 25;471(1-2):182-8. doi: 10.1016/j.ijpharm.2014.04.073. Epub 2014 May 13.
This paper describes the effect of powder compressibility and two process parameters of a dosator nozzle capsule filling machine on powder densification during plug formation. One process parameter was the ratio between the powder bed's depth and the length of the nozzle dosing chamber, hereinafter referred to as F. The other one was the speed of capsule filling. This paper demonstrates that powder densification during the capsule filling process is a function of the powder compressibility and the above process parameters (increasing them leads to higher plug density). The Walker model was used to characterize the compressibility of powders at low compression forces and the obtained compressibility coefficient W proved to be a good predictor of powder densification during the capsule filling process.
本文描述了粉末可压缩性以及定量给料喷嘴胶囊填充机的两个工艺参数对塞子形成过程中粉末致密化的影响。一个工艺参数是粉末床深度与喷嘴定量腔长度之比，以下简称F。另一个是胶囊填充速度。本文表明，胶囊填充过程中的粉末致密化是粉末可压缩性和上述工艺参数的函数（增加这些参数会导致更高的塞子密度）。使用沃克模型来表征低压缩力下粉末的可压缩性，所获得的可压缩系数W被证明是胶囊填充过程中粉末致密化的良好预测指标。
