Gustafson Kimara L, Eckerle Judith K, Howard Cynthia R, Andrews Beth, Polgreen Lynda E
1University of Minnesota, Minneapolis, MN, USA.
Clin Pediatr (Phila). 2013 Dec;52(12):1149-53. doi: 10.1177/0009922813495955. Epub 2013 Jul 19.
Vitamin D deficiency impairs bone health and development.
To determine the prevalence of and risk factors for vitamin D deficiency in pediatric international adoptees.
A prospective cohort (N = 189) study from a single international adoption clinic was conducted. Total 25-hydroxy vitamin D [25(OH)D] level was measured at the initial clinical assessment (within 6 months of adoption). Vitamin D deficiency was defined as a 25(OH)D <20 ng/mL (<8 nmol/L) and insufficiency as 25(OH)D <30 ng/mL (<12 nmol/L).
Vitamin D deficiency was diagnosed in 8% and insufficiency in 27% of the cohort. Lower body mass index and longer time in an institution were associated with vitamin D deficiency and insufficiency independent of age.
Vitamin D insufficiency was common in our cohort of international adoptees. The significance of vitamin D insufficiency on bone development during the typical "catch-up" growth following international adoption needs to be determined.
维生素D缺乏会损害骨骼健康和发育。
确定国际领养儿童中维生素D缺乏的患病率及其危险因素。
在一家国际领养诊所进行了一项前瞻性队列研究（N = 189）。在初次临床评估时（领养后6个月内）测量总25-羟基维生素D [25(OH)D]水平。维生素D缺乏定义为25(OH)D <20 ng/mL（<8 nmol/L），不足定义为25(OH)D <30 ng/mL（<12 nmol/L）。
该队列中8%被诊断为维生素D缺乏，27%为不足。较低的体重指数和在机构中的较长时间与维生素D缺乏和不足相关，且与年龄无关。
在我们的国际领养儿童队列中，维生素D不足很常见。需要确定维生素D不足在国际领养后典型的“追赶”生长期间对骨骼发育的影响。
