Department of Pediatric and Adolescent Medicine, Children's Center, Mayo Clinic, Rochester, MN.
Division of Allergic Disease, Department of Medicine, Mayo Clinic, Rochester, MN.
J Pediatr. 2021 Dec;239:212-218.e2. doi: 10.1016/j.jpeds.2021.07.037. Epub 2021 Jul 20.
To determine the trends in testing and incidence of vitamin D deficiency/insufficiency in Olmsted County, Minnesota over a 16-year period.
The Rochester Epidemiology Project (REP) was used to identify Olmsted County, Minnesota residents aged <19 years who had 25-hydroxyvitamin D [25(OH)D] levels measured between January 2, 2002 and December 31, 2017. Using each patient's first 25(OH)D measurement during this period, patients were categorized into 3 groups: <20 ng/mL, 20-50 ng/mL, and >50 ng/mL. Vitamin D deficiency/insufficiency was defined as a total 25(OH)D level of <20 ng/mL.
There was a 42-fold increase in the proportion of the county's pediatric population tested each year, starting at 3.7 per 10 000 persons in 2002 and increasing to 156.1 per 10 000 persons in 2017. The largest increase in testing occurred in children aged ≥10 years, specifically the females in this age group, in whom we observed a 90-fold increase from 2002 to 2017. During the 16-year period, the incidence of vitamin D deficiency/insufficiency (per 10 000 persons) increased from 1.7 in 2002-2003 to 19.9 in 2016-2017, but the proportion that were tested and had vitamin D deficiency/insufficiency remained stable, with rates of 21.9% (95% CI, 16.1%-29.1%) in 2006-2007 and 18.5% (95% CI, 16.0%-21.2%) in 2016-2017.
The proportion of the county's pediatric population who underwent vitamin D testing increased from 2002 to 2017, in parallel to the increased incidence of vitamin D deficiency/insufficiency, but the proportion tested that had vitamin D deficiency/insufficiency remained stable over time.
在 16 年期间，确定明尼苏达州奥姆斯特德县检测和维生素 D 缺乏/不足发病率的趋势。
罗切斯特流行病学项目（REP）用于确定 2002 年 1 月 2 日至 2017 年 12 月 31 日期间在奥姆斯特德县年龄<19 岁的明尼苏达州居民，他们的 25-羟维生素 D [25（OH）D]水平进行了测量。在此期间，每位患者的首次 25（OH）D 测量值用于将患者分为 3 组：<20ng/mL、20-50ng/mL 和>50ng/mL。维生素 D 缺乏/不足定义为总 25（OH）D 水平<20ng/mL。
该县儿科人群每年接受检测的比例增加了 42 倍，从 2002 年的每 10000 人 3.7 人增加到 2017 年的每 10000 人 156.1 人。检测量最大的增加发生在≥10 岁的儿童中，特别是在该年龄组的女性中，我们观察到从 2002 年到 2017 年增加了 90 倍。在 16 年期间，维生素 D 缺乏/不足的发病率（每 10000 人）从 2002-2003 年的 1.7 增加到 2016-2017 年的 19.9，但接受检测和患有维生素 D 缺乏/不足的比例保持稳定，2006-2007 年为 21.9%（95%CI，16.1%-29.1%），2016-2017 年为 18.5%（95%CI，16.0%-21.2%）。
从 2002 年到 2017 年，该县儿科人群接受维生素 D 检测的比例增加，与维生素 D 缺乏/不足的发病率增加平行，但随时间推移，接受检测且患有维生素 D 缺乏/不足的比例保持稳定。
