Neuropharmacology Division, Department of Pharmacology, I.S.F. College of Pharmacy, Moga 142001, Punjab, India.
Pharmacol Biochem Behav. 2013 Sep;110:174-84. doi: 10.1016/j.pbb.2013.07.003. Epub 2013 Jul 17.
Glutamate and γ-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter systems, respectively in the central nervous system (CNS). Dysregulation, in any of these or both, has been implicated in various CNS disorders. GABA acts via ionotropic (GABA(A) and GABA(C) receptor) and metabotropic (GABA(B)) receptor. Dysregulation of GABAergic signaling and alteration in GABA(B) receptor expression has been implicated in various CNS disorders. Clinically, baclofen-a GABA(B) receptor agonist is available for the treatment of spasticity, dystonia etc., associated with various neurological disorders. Moreover, GABAB receptor ligands has also been suggested to be beneficial in various neuropsychiatric and neurodegenerative disorders. The present review is aimed to discuss the role of GABA(B) receptors and the possible outcomes of GABA(B) receptor modulation in CNS disorders.
谷氨酸和γ-氨基丁酸（GABA）分别是中枢神经系统（CNS）中的主要兴奋性和抑制性神经递质系统。这些系统或两者中的任何一个失调都与各种 CNS 疾病有关。GABA 通过离子型（GABA(A)和 GABA(C)受体）和代谢型（GABA(B)受体）受体起作用。GABA 能信号转导的失调和 GABA(B)受体表达的改变与各种 CNS 疾病有关。临床上，巴氯芬 - GABA(B)受体激动剂可用于治疗与各种神经疾病相关的痉挛、肌张力障碍等。此外，GABAB 受体配体也被认为对各种神经精神和神经退行性疾病有益。本综述旨在讨论 GABA(B)受体的作用以及 GABA(B)受体调节在 CNS 疾病中的可能结果。
