Department of Cardiology, Tel-Aviv Sourasky Medical Center and Sackler School of Medicine, Tel-Aviv University, Israel.
Heart Rhythm. 2013 Sep;10(9):1375-82. doi: 10.1016/j.hrthm.2013.07.030. Epub 2013 Jul 19.
Fever is known to unmask the Brugada pattern on the electrocardiogram (ECG) and trigger ventricular arrhythmias in patients with Brugada syndrome. Genetic studies in selected cases with fever-induced Brugada pattern have identified disease-causing mutations. Thus, "fever-induced Brugada" is a recognized clinical entity. However, its prevalence has not been systematically evaluated.
The purpose of this study was to assess the prevalence of Brugada pattern in consecutive patients with fever.
ECGs of patients with fever admitted to the emergency department were evaluated for the presence of Brugada pattern and compared with ECGs of consecutive nonfebrile patients.
ECGs of 402 patients with fever and 909 without were evaluated. Type I Brugada pattern was 20 times more common in the febrile group than in the afebrile group (2% vs. 0.1%, respectively, P = .0001). All patients with fever-induced type I Brugada pattern were asymptomatic and remained so during 30 months of follow-up.
Type I Brugada pattern is definitively more common among patients with fever, suggesting that asymptomatic Brugada syndrome is more prevalent than previously estimated.
发热已知可使心电图（ECG）上的 Brugada 图形显现，并在 Brugada 综合征患者中引发室性心律失常。在发热诱导 Brugada 图形的选定病例中进行的遗传研究已确定了致病突变。因此，“发热诱导 Brugada”是一种公认的临床实体。然而，其患病率尚未得到系统评估。
本研究旨在评估发热患者 Brugada 图形的患病率。
评估急诊科发热患者的心电图是否存在 Brugada 图形，并与连续非发热患者的心电图进行比较。
共评估了 402 例发热患者和 909 例无发热患者的心电图。发热组的 I 型 Brugada 图形比无发热组常见 20 倍（分别为 2%和 0.1%，P=0.0001）。所有发热诱导的 I 型 Brugada 图形患者均无症状，在 30 个月的随访中仍无症状。
发热患者中 I 型 Brugada 图形确实更为常见，这表明无症状 Brugada 综合征比先前估计的更为普遍。
