Dipartimento di Scienze e Innovazione Tecnologica and Nano-SiSTeMI Interdisciplinary Centre, Università del Piemonte Orientale A. Avogadro (Italy), Via Michel 11, I-15121 Alessandria, Italy.
Phys Chem Chem Phys. 2013 Aug 28;15(32):13418-33. doi: 10.1039/c3cp51235e.
Layered double hydroxides (LDH) are versatile materials used for intercalating bioactive molecules, both in pharmaceutical and cosmetic fields, with the purpose of protecting them from degradation, enhancing their water solubility to increase bioavailability, and/or obtaining modified release properties. The properties of the intercalation compounds of Mg/Al_LDH and Zn/Al_LDH with different drugs and sunscreens, namely diclofenac, ketoprofen, gliclazide, retinoic acid, furosemide, para-aminobenzoic acid and 2-phenylbenzimidazolsulfonic (Eusolex) acid, have been studied by crystallographic, spectroscopic and thermogravimetric techniques and by solid state NMR, to shed light on their structure, their molecular interactions and their stability from the thermal and chemical viewpoint. The structural features were described with particular attention to the interaction between the organic and inorganic components and to the stability of the intercalation products. For the first time two synchrotron radiation powder diffraction patterns of organic-containing LDH were solved and refined by Rietveld methods to obtain an experimental crystal structure.
层状双氢氧化物（LDH）是一种多功能材料，可用于将生物活性分子插入其中，无论是在制药还是化妆品领域，目的是保护它们免受降解，提高其水溶性以增加生物利用度，和/或获得改良的释放性能。用不同的药物和防晒霜（即双氯芬酸、酮洛芬、格列齐特、维甲酸、呋塞米、对氨基苯甲酸和 2-苯并咪唑磺酸钠（Eusolex）酸）对 Mg/Al_LDH 和 Zn/Al_LDH 的插层化合物的性质进行了晶体学、光谱学和热重分析以及固态 NMR 研究，以阐明它们的结构、分子相互作用以及从热和化学角度来看它们的稳定性。结构特征被特别描述，特别注意有机和无机成分之间的相互作用以及插层产物的稳定性。首次通过 Rietveld 方法解决并细化了两个含有有机物质的 LDH 的同步辐射粉末衍射图，以获得实验晶体结构。
