[羧基离子载体莫能菌素对心脏和血流动力学影响的实验研究]
[An experimental study of the cardio- and hemodynamic effects of the carboxyl ionophore monensin].
作者信息
Gurbanov K G, Kovalev G V, Paperno A A
出版信息
Farmakol Toksikol. 1990 May-Jun;53(3):17-9.
PMID:2387374
Abstract
The effect of ionophore monensin on the main parameters of cardio- and hemodynamics was studied in the experiments on anesthetized cats. Monensin (0.075-0.375 mg/kg) administered intravenously in the increasing doses was shown to produce the dose-dependent elevation of arterial blood pressure, the increase of myocardial contractility and the total peripheral resistance. A single administration of monensin (0.375 mg/kg) was found to exert the two-phase action on the parameters of cardio- and hemodynamics.
摘要
在麻醉猫的实验中研究了离子载体莫能菌素对心脏和血流动力学主要参数的影响。静脉内递增剂量给予莫能菌素（0.075 - 0.375毫克/千克），结果显示会导致动脉血压呈剂量依赖性升高、心肌收缩力增强以及总外周阻力增加。单次给予莫能菌素（0.375毫克/千克）被发现对心脏和血流动力学参数有两阶段作用。
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