Kovalev G V, Gurbanov K G, Luk'ianenko N G, Basok S S
Farmakol Toksikol. 1988 May-Jun;51(3):36-8.
The cardio- and hemodynamic effects of the derivative of aza-15-crown-5 was studied in acute experiments on anesthetized (ethaminal sodium, 50 mg/kg) cats. At intravenous administration the compound was found to induce hypotension, to dilate arterial vessels, to exert negative ino- and chronotropic effects, to decrease the cardiac output. The pharmacological analysis suggests that the mechanism of the cardiotropic action of the compound is due to its intervention in calcium ion metabolism.
在对麻醉（戊巴比妥钠，50毫克/千克）猫进行的急性实验中，研究了氮杂-15-冠-5衍生物的心脏和血流动力学效应。静脉给药时，发现该化合物可诱发低血压、扩张动脉血管、产生负性肌力和变时作用、降低心输出量。药理学分析表明，该化合物的心脏作用机制是由于其干预了钙离子代谢。
