一名患有与鞘内化疗相关的脊髓病患者的磁共振成像显示侧柱和后柱高信号。
Lateral and dorsal column hyperintensity on magnetic resonance imaging in a patient with myelopathy associated with intrathecal chemotherapy.
作者信息
Saito Fumine, Hatano Taku, Hori Masaaki, Kawamura Miwako, Sasaki Makoto, Aoki Shigeki, Hattori Nobutaka
机构信息
Department of Neurology, Department of Internal Medicine, Tokyo, Japan ; Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Case Rep Neurol. 2013 Jun 6;5(2):110-5. doi: 10.1159/000351848. Print 2013 May.
Chemotherapy-related myelopathy mimicking subacute combined degeneration (SCD) has rarely been reported. We encountered a 35-year-old female with sensory ataxia after intrathecal chemotherapy. Spinal magnetic resonance imaging showed localized abnormal signal areas in the lateral and dorsal white matter, mimicking SCD. Diffusion imaging showed restricted water diffusion and increased microstructural complexity, and cerebrospinal fluid analysis showed increased levels of myelin basic proteins, indicating demyelinating myelopathy. Advanced diffusion imaging can provide more information on the microstructure of chemotherapy-related myelopathy.
模仿亚急性联合变性（SCD）的化疗相关性脊髓病鲜有报道。我们遇到一名35岁女性，在鞘内化疗后出现感觉性共济失调。脊髓磁共振成像显示外侧和背侧白质有局限性异常信号区，类似SCD。扩散成像显示水扩散受限且微观结构复杂性增加，脑脊液分析显示髓鞘碱性蛋白水平升高，提示脱髓鞘性脊髓病。先进的扩散成像可为化疗相关性脊髓病的微观结构提供更多信息。
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