Department of Radiology, University of Lausanne, Lausanne, Switzerland.
PLoS One. 2013 Jul 16;8(7):e69294. doi: 10.1371/journal.pone.0069294. Print 2013.
MR structural T1-weighted imaging using high field systems (>3T) is severely hampered by the existing large transmit field inhomogeneities. New sequences have been developed to better cope with such nuisances. In this work we show the potential of a recently proposed sequence, the MP2RAGE, to obtain improved grey white matter contrast with respect to conventional T1-w protocols, allowing for a better visualization of thalamic nuclei and different white matter bundles in the brain stem. Furthermore, the possibility to obtain high spatial resolution (0.65 mm isotropic) R1 maps fully independent of the transmit field inhomogeneities in clinical acceptable time is demonstrated. In this high resolution R1 maps it was possible to clearly observe varying properties of cortical grey matter throughout the cortex and observe different hippocampus fields with variations of intensity that correlate with known myelin concentration variations.
MR 结构 T1 加权成像使用高场系统（>3T）受到现有大发射场不均匀性的严重阻碍。已经开发了新的序列来更好地应对这些干扰。在这项工作中，我们展示了一种新序列的潜力，即 MP2RAGE，与传统的 T1-w 协议相比，可以获得更好的灰白质对比度，从而更好地观察丘脑核和脑干中的不同白质束。此外，还证明了有可能在临床可接受的时间内获得完全独立于发射场不均匀性的高空间分辨率（0.65 毫米各向同性）R1 图谱。在这种高分辨率 R1 图谱中，可以清楚地观察到整个皮层中皮质灰质的不同特性，并观察到不同的海马区，其强度变化与已知的髓鞘浓度变化相关。
