[高尿酸血症与慢性肾脏病问题]

[Hyperuricemia and the problem of chronic kidney disease].

作者信息

Shcherbak A V, Kozlovskaia L V, Bobkova I N, Balkarov I M, Lebedeva M V, Stakhova T Iu

出版信息

Ter Arkh. 2013;85(6):100-4.

Abstract

The paper reviews the literature on the role of hyperuricemia as a risk factor for chronic kidney disease and as one of the factors for the progression of existing kidney disease. It gives epidemiological information on a relationship between hyperuricemia and kidney lesion. The mechanisms for the damaging action of uric acid on kidney tissue, which have experimentally and clinically observed, are considered. The main areas of hyperuricemia correction and its place in the total nephroprotection strategy are defined.

摘要

本文综述了关于高尿酸血症作为慢性肾脏病危险因素以及作为现有肾脏疾病进展因素之一的文献。它提供了高尿酸血症与肾脏病变之间关系的流行病学信息。探讨了实验和临床观察到的尿酸对肾脏组织损伤作用的机制。明确了高尿酸血症纠正的主要领域及其在整体肾脏保护策略中的地位。