[Glaucoma following the antidepressant mianserin].

Mianserin HC1 (Bolvidon) is a new antidepressant agent of the diperazino-azepine group, not related chemically to the tricyclic antidepressants. It lacks the basic side-chain considered to be responsible for the anticholinergic activity, including mydriasis, of the tricyclic antidepressants. Nevertheless, a 60-year-old woman developed acute angle closure glaucoma following administration of the drug. After the acute attack we performed argon laser iridotomies, followed with mianserin, without deleterious effects. We think that acute angle closure glaucoma might be a rare complication of mianserin in narrow angle glaucoma patients, in whom laser iridotomy is advisable.