Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, Georgia 30303, USA.
Org Lett. 2013 Aug 2;15(15):3910-3. doi: 10.1021/ol401666e. Epub 2013 Jul 22.
An enantioselective intramolecular indole aminohydroxylation reaction is catalyzed by iron(II)-chiral bisoxazoline (BOX) complexes (ee up to 99%, dr > 20:1). This discovery enables expedient asymmetric synthesis of a series of biologically active 3-amino oxindoles and 3-amino indolanes.
手性双噁唑啉（BOX）配合物铁（II）催化的对映选择性吲哚胺羟化反应（ee 最高达 99%，dr > 20:1）。这一发现使得一系列生物活性的 3-氨基氧化吲哚和 3-氨基吲哚啉的便捷不对称合成成为可能。
