Zhu Cheng-Liang, Lu Deng-Fu, Sears Jeffrey D, Jia Zhen-Xin, Xu Hao
Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA.
Synthesis (Stuttg). 2016 Sep;48(18):3031-3041. doi: 10.1055/s-0035-1562515. Epub 2016 Jul 25.
A set of practical synthetic procedures for the iron-catalyzed intermolecular olefin aminohydroxylation reactions in gram scale is reported. In these transformations, a bench-stable functionalized hydroxylamine is applied as the amination reagent. This method is compatible with a broad range of synthetically valuable olefins including those that are incompatible with the existing aminohydroxylation methods. It also provides valuable amino alcohol building blocks with regio- and stereo-chemical arrays that are complementary to known methods.
报道了一组用于铁催化克级分子间烯烃氨基羟基化反应的实用合成方法。在这些转化反应中，一种易于操作的官能化羟胺被用作胺化试剂。该方法与多种具有合成价值的烯烃兼容，包括那些与现有氨基羟基化方法不兼容的烯烃。它还提供了具有区域和立体化学排列的有价值的氨基醇结构单元，这些结构单元与已知方法互补。
