Foschini M P, Fulcheri E, Baracchini P, Ceccarelli C, Betts C M, Eusebi V
Istituti di Anatomia ed Istologia Patologica, Universitá di Bologna e di Genova, Italy.
Hum Pathol. 1990 Aug;21(8):859-65. doi: 10.1016/0046-8177(90)90057-c.
Three cases of a squamous cell carcinoma with a prominent myxoid stroma are reported. One case in a 70-year-old woman had presented as a lump in the breast, the other two presented as polypoid lesions of the larynx and cervix uteri in a 65-year-old man and 61-year-old woman, respectively. The carcinomatous component was immersed in abundant extracellular mucosubstances. In addition to occasional squamous pearls, it displayed immunocytochemical evidence of high-weight keratin present in the neoplastic cells and, in one case, desmosomal attachment under electron microscopy. The extracellular mucosubstances proved to be similar to those seen in connective tissue. The differential diagnosis with histologically similar lesions has been taken into consideration, and it has been suggested that this newly described entity showing abundant myxoid stroma has to be distinguished from numerous benign and malignant myxoid soft tissue tumors.
报告了3例具有显著黏液样间质的鳞状细胞癌。1例发生于一名70岁女性，表现为乳腺肿块；另外2例分别发生于一名65岁男性和一名61岁女性，分别表现为喉部和子宫颈的息肉样病变。癌组织成分浸润于丰富的细胞外黏液物质中。除偶尔可见鳞状上皮珠外，肿瘤细胞免疫细胞化学显示存在高分子量角蛋白，其中1例在电镜下可见桥粒连接。细胞外黏液物质被证实与结缔组织中的相似。已考虑与组织学相似病变的鉴别诊断，提示这种新描述的具有丰富黏液样间质的实体必须与众多良性和恶性黏液样软组织肿瘤相鉴别。
