环孢素A治疗可将感染杜氏利什曼原虫的C57BL/10（治愈型）小鼠转变为非治愈型表型。
Cyclosporin A treatment converts Leishmania donovani-infected C57BL/10 (curing) mice to a noncuring phenotype.
作者信息
Adinolfi L E, Bonventre P F
机构信息
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, Ohio 45267.
出版信息
Infect Immun. 1990 Sep;58(9):3151-3. doi: 10.1128/iai.58.9.3151-3153.1990.
Cyclosporin A prevents visceralization of Leishmania major infection of BALB/c mice (N. C. Behforouz, C. D. Wenger, and B. A. Mathison, J. Immunol. 136:3067-3075, 1986; W. Solbach, K. Forberg, E. Kammerer, C. Bogdan, and M. Rollinghoff, J. Immunol. 134:702-707, 1986). We report that cyclosporin A exacerbates disseminated leishmaniasis caused by L. donovani in C57BL/10 mice. Normal mice challenged with 5 x 10(6) amastigotes intravenously cleared the infection within several months by spontaneous acquisition of cell-mediated immunity. In contrast, cyclosporin A administered daily intraperitoneally at a dose of 1.25 mg per mouse prevented development of curative immunity and converted C57BL/10 (curing) mice to a noncuring phenotype. A rationale for the contrasting effects of cyclosporin A in the two murine models of leishmaniasis is provided.
环孢素A可防止利什曼原虫主要感染BALB/c小鼠的内脏病变（N.C.贝福鲁兹、C.D.温格和B.A.马西森，《免疫学杂志》136:3067 - 3075，1986；W.索尔巴赫、K.福尔贝格、E.卡默勒、C.博丹和M.罗林霍夫，《免疫学杂志》134:702 - 707，1986）。我们报告环孢素A会加剧C57BL/10小鼠由杜氏利什曼原虫引起的播散性利什曼病。用5×10⁶无鞭毛体静脉内攻击正常小鼠，小鼠会通过自发获得细胞介导免疫在数月内清除感染。相反，以每只小鼠1.25毫克的剂量每日腹腔注射环孢素A会阻止治愈性免疫的发展，并使C57BL/10（治愈型）小鼠转变为非治愈表型。本文提供了环孢素A在两种利什曼病小鼠模型中产生不同作用的理论依据。
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