González-Gómez A, Fránquiz J, García-Barreto D
Psychiatric Hospital of Havana, Cuba.
Int J Clin Pharmacol Ther Toxicol. 1990 Jul;28(7):292-7.
The effects of oral verapamil monotherapy (320 mg/day) given to a group of essential hypertensive patients (n = 16) on blood pressure, electrocardiogram (ECG) and ventricular function measured by means of nuclear ventriculography (NV) were investigated. Verapamil significantly lowered systolic (SP) (p less than 0.001) and diastolic (DP) (p less than 0.001) blood pressure. Left ventricular ejection fraction (LVEF) and ejection rate (LVER) were reduced from 61.61 +/- 6.34 to 54.16 +/- 6.09% (p less than 0.001) and from 255.6 +/- 58.9 to 217.4 +/- 56.03% (p less than 0.02), respectively. On the other hand, in the right ventricle, the drug only reduced the right ventricular filling rate (RVFR) from 225.2 +/- 60.02 to 167.5 +/- 43.7% (p less than 0.05). Total blood volume (TBV) was also significantly diminished (p less than 0.05). Variations in LVEF (delta LVEF) and RVEF (delta RVEF) correlated with variations in blood pressures and TVB (delta TVB). The results indicate that the hypotensive action mechanism of verapamil could be explained at least in part by a reduction in LVEF and systemic vasodilatation.
研究了对一组原发性高血压患者（n = 16）给予口服维拉帕米单一疗法（320毫克/天）对血压、心电图（ECG）以及通过核心室造影术（NV）测量的心室功能的影响。维拉帕米显著降低了收缩压（SP）（p < 0.001）和舒张压（DP）（p < 0.001）。左心室射血分数（LVEF）和射血速率（LVER）分别从61.61 ± 6.34降至54.16 ± 6.09%（p < 0.001）以及从255.6 ± 58.9降至217.4 ± 56.03%（p < 0.02）。另一方面，在右心室，该药物仅将右心室充盈速率（RVFR）从225.2 ± 60.02降至167.5 ± 43.7%（p < 0.05）。总血容量（TBV）也显著减少（p < 0.05）。LVEF（ΔLVEF）和右心室射血分数（ΔRVEF）的变化与血压和TVB（ΔTVB）的变化相关。结果表明，维拉帕米的降压作用机制至少部分可以通过LVEF降低和全身血管舒张来解释。
