Gonzalez-Gomez A, Cires Pujols M, Gamio Capestany F, Rodriguez de la Vega A, Garcia-Barreto D
Psychiatric Hospital of Havana, Cuba.
Int J Clin Pharmacol Ther Toxicol. 1988 Sep;26(9):453-60.
Twenty-seven hypertensive outpatients were studied to evaluate the efficacy of verapamil after a single oral dose as well as following a short-term treatment and also in combination with oxprenolol. Blood pressure was significantly reduced (p 0.01) after verapamil monotherapy and the combined treatment. PR interval was lengthened from 30 min to 4 h during acute testing, and also after short-term treatment. QT was only prolonged after the verapamil monotherapy. Systolic time intervals (STIs) were not modified, except left ventricular ejection time (LVETc). Direct correlations were found among verapamil plasma concentrations and changes provoked on blood pressure and PR interval. The mean side effects found were disturbance of atrioventricular conduction in two patients without ulterior complications. The results suggest that verapamil monotherapy or in combination with oxprenolol could be useful in the treatment of essential hypertension.
对27例高血压门诊患者进行了研究，以评估单次口服维拉帕米后的疗效、短期治疗后的疗效以及与氧烯洛尔联合使用时的疗效。维拉帕米单药治疗及联合治疗后血压显著降低（p<0.01）。急性试验期间以及短期治疗后，PR间期从30分钟延长至4小时。仅维拉帕米单药治疗后QT间期延长。除左心室射血时间（LVETc）外，收缩期时间间期（STIs）未改变。维拉帕米血浆浓度与血压和PR间期的变化之间存在直接相关性。发现的平均副作用是2例患者出现房室传导障碍，无其他并发症。结果表明，维拉帕米单药治疗或与氧烯洛尔联合使用可能对原发性高血压的治疗有用。
