Department of Chemistry, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov;115:641-7. doi: 10.1016/j.saa.2013.06.086. Epub 2013 Jul 3.
Recent advances in oncology are focused on developing new complexes of gold(III) with various ligands that show augmented anti-proliferative potential and reduced toxicity as compared to cis-platin. In this study, new Au(III) complexes of the type [(thione)2Au(diamine)]Cl3 are reported, where thione=1,3-imidazolidine-2-thione (Imt), 1,3-Diazinane-2-thione (Diaz) and diamine=1,2-diaminoethane (en), 1,3-diaminopropane (pn) or 1,4-diaminobutane (bn). The solid state IR as well as (13)C and (15)N NMR data indicate that Au(III) center is bonded via sulfur of thiocarbonyl SC site of the thiones and also chelated by the diamines from the trans side of coordinated thiones. Spectroscopic data are evaluated by comparisons with calculated data from the built and optimized structure by GAUSSIAN 09 at the RB3LYP level with LanL2DZ bases set. These new Au(III) complexes based on mixed thione and diamine ligands are very similar to the square planar structure of tetracoordinate [Au(en)2]Cl3complex. In this study, cytotoxicity data for these gold(III) complexes against C6 glioma cell lines are also reported, and the results indicate some complexes have cytotoxicity comparable to cis-platin.
近年来，肿瘤学的研究重点集中在开发新型金（III）配合物，与顺铂相比，这些配合物具有增强的抗增殖潜力和降低的毒性。在这项研究中，报告了新型 [(硫酮)2Au（二胺)]Cl3 型 Au(III)配合物，其中硫酮=1,3-咪唑烷-2-硫酮 (Imt)、1,3-二嗪烷-2-硫酮 (Diaz) 和二胺=1,2-乙二胺 (en)、1,3-丙二胺 (pn) 或 1,4-丁二胺 (bn)。固态 IR 以及 (13)C 和 (15)N NMR 数据表明，Au(III) 中心通过硫代羰基 SC 位的硫酮的硫原子以及通过配位硫酮的反式侧的二胺进行键合。通过与在 GAUSSIAN 09 程序中使用 RB3LYP 水平和 LanL2DZ 基组构建和优化结构的计算数据进行比较，评估了光谱数据。这些基于混合硫酮和二胺配体的新型 Au(III)配合物非常类似于四配位 [Au(en)2]Cl3 配合物的正方形平面结构。在这项研究中，还报告了这些金（III）配合物对 C6 神经胶质瘤细胞系的细胞毒性数据，结果表明一些配合物具有与顺铂相当的细胞毒性。
