Marsico Fabio, Parente Antonio, Paolillo Stefania, Casaretti Laura, Lo Iudice Francesco, Pirozzi Elisabetta, Conte Sirio, Iardino Elisabetta, Gambardella Francesco, Della Ratta Giuseppe Luca, Cirillo Annapaola, Vitagliano Alice, Filardi Pasquale Perrone
Dipartimento di Scienze Biomediche Avanzate, Università degli Studi Federico II, Napoli, Italy.
G Ital Cardiol (Rome). 2013 Jul-Aug;14(7-8):517-25. doi: 10.1714/1308.14460.
Systemic inflammatory diseases are associated with increased cardiovascular morbidity and mortality. The link between inflammatory and cardiovascular diseases can be attributed to the coexistence of classical risk factors and inflammatory mechanisms activated during systemic inflammatory diseases involving the immune system. Unfavorable metabolic effects of anti-inflammatory drugs can also contribute to increase cardiovascular risk. Yet, clinical implications of these findings are not entirely clear, and deeper knowledge and awareness of cardiac involvement in inflammatory diseases are necessary. The aim of this review is to summarize cardiac involvement in systemic inflammatory diseases and to identify aspects where evidence is currently lacking that would deserve further investigation in the future.
全身性炎症性疾病与心血管疾病发病率和死亡率的增加相关。炎症性疾病与心血管疾病之间的联系可归因于经典危险因素的共存以及全身性炎症性疾病（涉及免疫系统）期间激活的炎症机制。抗炎药物的不良代谢作用也可能导致心血管风险增加。然而，这些发现的临床意义尚不完全清楚，深入了解和认识炎症性疾病中的心脏受累情况很有必要。本综述的目的是总结全身性炎症性疾病中的心脏受累情况，并确定目前证据不足但未来值得进一步研究的方面。
