优化暴露前和暴露后预防措施的依从性：采用综合生物行为方法的必要性。
Optimizing adherence to preexposure and postexposure prophylaxis: the need for an integrated biobehavioral approach.
作者信息
Blashill Aaron J, Ehlinger Peter P, Mayer Kenneth H, Safren Steven A
机构信息
Department of Psychiatry, Massachusetts General Hospital Harvard Medical School Fenway Health.
Department of Psychiatry, Massachusetts General Hospital.
出版信息
Clin Infect Dis. 2015 Jun 1;60 Suppl 3(Suppl 3):S187-90. doi: 10.1093/cid/civ111.
Abstract
Preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) has been shown to be effective in preventing transmission of human immunodeficiency virus (HIV). A dose-response relationship between adherence and HIV transmission is illustrated in the current PrEP literature, and adherence interventions for PrEP may be useful, although currently few effective programs have been developed and tested. There is a paucity of randomized controlled trials testing PEP adherence interventions, and further research is needed. We conclude by proposing the importance of tailoring adherence counseling to address psychosocial factors and mental health stressors that may negatively affect adherence.
摘要
暴露前预防（PrEP）和暴露后预防（PEP）已被证明在预防人类免疫缺陷病毒（HIV）传播方面有效。当前的PrEP文献表明了依从性与HIV传播之间的剂量反应关系，PrEP的依从性干预可能会有用，尽管目前很少有有效的项目得到开发和测试。测试PEP依从性干预的随机对照试验很少，还需要进一步研究。我们最后提出，针对可能对依从性产生负面影响的心理社会因素和心理健康压力源，量身定制依从性咨询非常重要。
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