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猴子海马体在视觉探索和记忆形成过程中的振荡活动。

Oscillatory activity in the monkey hippocampus during visual exploration and memory formation.

机构信息

Yerkes National Primate Research Center, Atlanta, GA 30329, USA.

出版信息

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13144-9. doi: 10.1073/pnas.1302351110. Epub 2013 Jul 22.

Abstract

Primates explore the visual world through the use of saccadic eye movements. Neuronal activity in the hippocampus, a structure known to be essential for memory, is modulated by this saccadic activity, but the relationship between visual exploration through saccades and memory formation is not well understood. Here, we identify a link between theta-band (3-12 Hz) oscillatory activity in the hippocampus and saccadic activity in monkeys performing a recognition memory task. As monkeys freely explored novel images, saccades produced a theta-band phase reset, and the reliability of this phase reset was predictive of subsequent recognition. In addition, enhanced theta-band power before stimulus onset predicted stronger stimulus encoding. Together, these data suggest that hippocampal theta-band oscillations act in concert with active exploration in the primate and possibly serve to establish the optimal conditions for stimulus encoding.

摘要

灵长类动物通过扫视眼动探索视觉世界。海马体中的神经元活动,已知对记忆至关重要,会受到这种扫视活动的调节,但扫视活动和记忆形成之间的关系还不太清楚。在这里,我们在执行识别记忆任务的猴子中发现了海马体中θ波段(3-12 Hz)振荡活动与扫视活动之间的联系。当猴子自由地探索新图像时,扫视会产生θ波段相位重置,并且这种相位重置的可靠性可以预测后续的识别。此外,刺激前增强的θ波段功率可以预测更强的刺激编码。总之,这些数据表明,海马体的θ波段振荡与灵长类动物的主动探索协同作用,可能有助于为刺激编码建立最佳条件。

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