Buffalo Elizabeth A
Department of Neurobiology and Biophysics, University of Washington School of Medicine, Washington National Primate Research Center, Seattle, Washington, USA.
Hippocampus. 2025 Jan;35(1):e23673. doi: 10.1002/hipo.23673.
During the 1990s and early 2000s, research in humans and in the nonhuman primate model of human amnesia revealed that tasks involving free viewing of images provided an exceptionally sensitive measure of recognition memory. Performance on these tasks was sensitive to damage restricted to the hippocampus as well as to damage that included medial temporal lobe cortices. Early work in my laboratory used free-viewing tasks to assess the neurophysiological correlates of recognition memory, and the use of naturalistic visual exploration opened rich avenues to assess other aspects of the impact of eye movements on neural activity in the hippocampus and entorhinal cortex. Here, I summarize two main lines of this work and some of the stories of the trainees who made essential contributions to these discoveries.
在20世纪90年代和21世纪初，针对人类以及人类失忆症的非人类灵长类动物模型开展的研究表明，涉及自由观看图像的任务为识别记忆提供了一种极其灵敏的测量方法。这些任务的表现对仅局限于海马体的损伤以及包括内侧颞叶皮质的损伤都很敏感。我实验室早期的研究工作利用自由观看任务来评估识别记忆的神经生理相关性，而自然视觉探索的运用为评估眼动对海马体和内嗅皮质神经活动影响的其他方面开辟了丰富的途径。在此，我总结这项工作的两条主要思路，以及一些为这些发现做出重要贡献的受训人员的故事。
