人类系统性红斑狼疮在严重联合免疫缺陷（SCID）小鼠中的转移。
Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice.
作者信息
Duchosal M A, McConahey P J, Robinson C A, Dixon F J
机构信息
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
出版信息
J Exp Med. 1990 Sep 1;172(3):985-8. doi: 10.1084/jem.172.3.985.
Abstract
To study the role of peripheral blood leukocytes (PBL) in the pathogenesis of human systemic lupus erythematosus (SLE), we transferred PBL from 5 SLE patients into 15 severe combined immunodeficiency (SCID) mice. Such reconstituted mice showed long-term presence of auto-antibodies characteristic of the donor in their sera, as well as human immunoglobulin deposition, and in some cases mouse C3, in the renal glomeruli. SCID mice repopulated with PBLs from normal donors do not develop serologic abnormalities or immunodeposits. It is concluded that human SLE serology and some associated renal changes can be reproduced solely by PBL transferred from afflicted patients, and that SCID-human-SLE mice may serve as an in vivo laboratory model for the study of human SLE.
摘要
为研究外周血白细胞（PBL）在人类系统性红斑狼疮（SLE）发病机制中的作用，我们将5例SLE患者的PBL移植到15只严重联合免疫缺陷（SCID）小鼠体内。这些重建小鼠的血清中长期存在供体特征性的自身抗体，以及人类免疫球蛋白沉积，在某些情况下，肾小球中还存在小鼠C3。用正常供体的PBL重新填充的SCID小鼠不会出现血清学异常或免疫沉积物。结论是，仅通过患病患者转移的PBL就可以重现人类SLE血清学和一些相关的肾脏变化，并且SCID-人-SLE小鼠可作为研究人类SLE的体内实验室模型。
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