L3T4+ T细胞对MRL-lpr/lpr小鼠淋巴细胞增殖和自身抗体产生的作用。
The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice.
作者信息
Santoro T J, Portanova J P, Kotzin B L
机构信息
Department of Medicine, Veterans Administration Medical Center, Denver, Colorado 80220.
出版信息
J Exp Med. 1988 May 1;167(5):1713-8. doi: 10.1084/jem.167.5.1713.
Abstract
The current study examines the role of the L3T4 T cell subset in the development of lupus-like autoimmunity and lymphoproliferation in lpr-bearing mice. Chronic treatment of MRL-lpr/lpr mice with anti-L3T4 antibody beginning at 4 wk old was found to markedly decrease the production of IgG anti-DNA and antihistone antibodies, while having no effect on IgM autoantibodies. A dramatic reduction in splenomegaly and lymphadenopathy was also observed coincident with a decrease in the percentage and total number of Thy-1+, B220+ cells. Together, the data suggest an important role for L3T4+ T cells in the pathogenesis of disease in lpr mice and provide further evidence that a requirement for the L3T4 subset may be a common feature of murine autoimmunity.
摘要
本研究探讨了L3T4 T细胞亚群在携带lpr基因的小鼠发生狼疮样自身免疫和淋巴细胞增殖过程中的作用。发现从4周龄开始用抗L3T4抗体长期治疗MRL-lpr/lpr小鼠，可显著降低IgG抗DNA和抗组蛋白抗体的产生，而对IgM自身抗体无影响。同时还观察到脾肿大和淋巴结病明显减轻，伴随Thy-1+、B220+细胞百分比和总数的减少。这些数据共同表明L3T4+ T细胞在lpr小鼠疾病发病机制中起重要作用，并进一步证明对L3T4亚群的需求可能是小鼠自身免疫的一个共同特征。
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