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微囊藻毒素 MC-LW 和 MC-LF 在荷兰地表水的出现及其对总微囊藻毒素毒性的贡献。

Occurrence of the microcystins MC-LW and MC-LF in Dutch surface waters and their contribution to total microcystin toxicity.

机构信息

Aquatic Ecology & Water Quality Management Group, Wageningen University, PO Box 47, Wageningen 6700 AA, The Netherlands.

出版信息

Mar Drugs. 2013 Jul 22;11(7):2643-54. doi: 10.3390/md11072643.

DOI:10.3390/md11072643
PMID:23880934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3736443/
Abstract

Microcystins (MCs) are the most frequently found cyanobacterial toxins in freshwater systems. Many MC variants have been identified and variants differ in their toxicity. Recent studies showed that the variants MC-LW and MC-LF might be more toxic than MC-LR, the variant that is most abundant and mostly used for risk assessments. As little is known about the presence of these two variants in The Netherlands, we determined their occurrence by analyzing 88 water samples and 10 scum samples for eight MC variants ((dm-7-)MC-RR, MC-YR, (dm-7-)MC-LR, MC-LY, MC-LW and MC-LF) by liquid chromatography with tandem mass spectrometry detection. All analyzed MC variants were detected, and MC-LW and/or MC-LF were present in 32% of the MC containing water samples. When MC-LW and MC-LF were present, they contributed to nearly 10% of the total MC concentrations, but due to their suspected high toxicity, their average contribution to the total MC toxicity was estimated to be at least 45%. Given the frequent occurrence and possible high toxicity of MC-LW and MC-LF, it seems better to base health risk assessments on the toxicity contributions of different MC variants than on MC-LR concentrations alone.

摘要

微囊藻毒素（MCs）是淡水系统中最常见的蓝藻毒素。已经鉴定出许多 MC 变体，它们的毒性不同。最近的研究表明，变体 MC-LW 和 MC-LF 可能比 MC-LR 更具毒性，而 MC-LR 是最丰富且主要用于风险评估的变体。由于对这两种变体在荷兰的存在知之甚少，我们通过分析 88 个水样和 10 个浮渣样本来确定它们的存在，方法是通过液相色谱串联质谱检测来分析八种 MC 变体（（dm-7-）MC-RR、MC-YR、（dm-7-）MC-LR、MC-LY、MC-LW 和 MC-LF）。所有分析的 MC 变体都被检测到，含有 MC 的水样中有 32%存在 MC-LW 和/或 MC-LF。当 MC-LW 和 MC-LF 存在时，它们占总 MC 浓度的近 10%，但由于它们可能具有高毒性，它们对总 MC 毒性的平均贡献估计至少为 45%。鉴于 MC-LW 和 MC-LF 的频繁出现和可能的高毒性，似乎最好根据不同 MC 变体的毒性贡献来进行健康风险评估，而不仅仅是基于 MC-LR 浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/d6713514d790/marinedrugs-11-02643-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/2b9e4e6b24a4/marinedrugs-11-02643-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/d43c7603b575/marinedrugs-11-02643-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/327aa809ab85/marinedrugs-11-02643-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/d6713514d790/marinedrugs-11-02643-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/2b9e4e6b24a4/marinedrugs-11-02643-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/d43c7603b575/marinedrugs-11-02643-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/327aa809ab85/marinedrugs-11-02643-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43cf/3736443/d6713514d790/marinedrugs-11-02643-g004.jpg

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